Archive for April 19th, 2008

So, it’s nice to see you all down there. I always wondered what earth looked like from way up where in I am space right now. It is actually quite realistic from the pictures they show you from the shuttles and all of that. And I’ve finally gotten to experience anti-gravity! I have wanted to do that ever since I was a child! It’s like a dream come true!

*PA laughs*

No, no…I’m just on my bed, typing away on MacBook as you all are thinking. However, I really do feel like I am in outer space or at least in some other…land?

I wanted to post about something else today but shall do that tomorrow–obviously this takes priority as it’s just so…whoa. I mean, Merlin #1 and I? I think we made an interesting decision here!

I took the first 100mg increase of my Topamax/Topiramate last night as I said I would since all of my appointments were done as of yesterday. If memory serves, because my cognitive abilities are extremely screwed right now (will get to that in more detail re: ACs and Topamax) I waited a little bit before taking my Seroquel/Quetiapine before bedtime. Wow, am I glad I made the decision to wait until the weekend!

I didn’t go to bed extremely late last night (did I…?…oh, fucking memory…did I come home and watch a bit of television?) I know I sent off a quick email and that was around 2230hrs. That means I must have gotten home around 2200hrs or so–maybe earlier? The late arrival home was because I called Grocery Man as I thought he would be getting off from work at around the time I would be arriving back in the neighbourhood. I thought it might be nice for a visit. It turned out he was sick with a bit of a cold and had taken the day off but no problem. So we had a visit, listened to some music and had some soup and toast for dinner. It was a rough week so I did get a wee bit tippled on some whisky.

I know. Right on the heels of talking with Prester John (now known as Greybeard) about drinking on Valium. Not to worry, kids. Again, just a bit of relief and relaxation because of all of the stress. However, I will note that initially it did seem to make PA a pretty cheap date. Then it just seemed to move off to…well, who knows? Regular PA drinking? Or maybe there was still some Valium/alcohol combined effect going on? I had taken the 5mg dose early in the morning. *PA shrugs*

So back to the good ol’ Topamax. Indeed, had I taken it the night before last, I don’t even know if I would have been able to make it to my appointment! I have been outside for a tea (not that it’s making a sachet of a difference) and a cigarette and I’ve just been walking around in circles. No, I was almost literally walking around in circles outside! Escher called and knows I’m on another crazy med overhaul and asked if I needed anything as I am obviously incapable of leaving the house right now. I told him that I am fine but might need some milk tomorrow as I am getting low on that. He said to call if so.

You know, speaking of cognitive impairment (I know…I said I’d get there re: the meds…) he’s right fucked. He said he was going back to work and now he’s not and I don’t know! I think he may have forgotten that I loaned him money. It was only sixty bucks/dollars/quid/euros/pounds…whatever you wish. I really don’t care if he pays me back. The funds are now gone from “PA International Mortgage And Loan.” The institution is filing for bankruptcy. Unfortunately, it may turn the world economy into yet another tailspin but that is just how Big Business goes sometimes.

Alright…Topamax and cognitive impairment. I apologize for it taking so long for me to get here but you obviously can understand why?

Now, all meds can come with some generalized side effects based upon their classes which pretty much makes sense–even if we still don’t know exactly how they work on our brains. With ACs, one of the biggies is cognitive impairment (followed by clumsiness!) Why the clumsiness, I’m not sure but the cognitive impairment? Maybe to do with GABA and Glutamic Acid and when it gets turned into Glutamate–a precursor to GABA. GABA is linked to memory? GABA is linked to seizures and the meds are of course Anticonvulsants–originally prescribed for seizures and Epilepsy.

But again, the clumsiness? Maybe if you get so stoopid you bump into things all the time? What bloody neurotransmitter is responsible for being swift and agile?!

Still, they are a very poorly misunderstood class of med and I believe this (at least for one reason) because they are so “multi-purpose.” They are used to treat seizures, Bipolar and migraines! I have always been so interested in possible links between the three–especially since I have them all! Others out there share the comorbidities as well. Maybe not all three but two of them.

I really think that Topamax is the worst in this area–the clumsiness/stoopid business. Some people may disagree. It was probably tied for the hardest hitting side effect for me along with loss of appetite/weight. Then there was the taste perversion (some things just tasted like crap!) and the paraesthesia (I got tingly in my extremeties.) The latter two went away and I did end up gaining a bit more weight and some of my appetite did come back. Also, a little less cognitive impairment but it’s still there (forgetting words: their names, meanings, spellings; I can get lost and turned around so easily, problems with memory…things like that?) Also, I’m on Lamictal/Lamotrigine so what does that have to offer me? I think I am a bit more clumsy now. Maybe a bit more cognitively impaired too? *PA rolls eyes*

Alright, I guess this is long enough. I did manage to write it too instead of just saying, “Hi, the Topamax has done me in. Laters.” And I don’t think there is any need for my Valium today? *laughing* Oh…PA turns into a little puddle on the floor. Unless for some reason I get really anxious about something…